Peer-reviewed veterinary case report
Three-dimensional time-of-flight magnetic resonance angiography of intracranial vessels in a canine model of ischemic stroke with permanent occlusion of the middle cerebral artery.
- Journal:
- Comparative medicine
- Year:
- 2009
- Authors:
- Kang, Byeong-Teck et al.
- Affiliation:
- Department of Veterinary Internal Medicine · South Korea
- Species:
- dog
Plain-English summary
This study looked at how well a special type of imaging called 3-dimensional time-of-flight magnetic resonance angiography (TOF-MRA) can help understand a model of stroke in dogs. Researchers caused a stroke in five healthy Beagle dogs by blocking a major artery in the brain. They took images before the stroke and again three and ten days later. In three of the dogs, they found complete blockage of the artery, along with signs of brain damage, while the other two had partial blockage and less severe damage. The findings suggest that TOF-MRA could be a useful tool for examining blood flow issues in dogs with this type of stroke.
Abstract
The purpose of this study was to evaluate the potential efficacy of 3-dimensional time-of-flight magnetic resonance angiography (TOF-MRA) to validate a canine ischemic stroke model. Ischemic stroke was induced through permanent middle cerebral artery occlusion (MCAO) in 5 healthy Beagle dogs. T2-turbo spin echo images and TOF-MRA were obtained with a 1.5-T magnetic resonance system before and 3 and 10 d after MCAO. In 3 dogs, angiograms of the brain obtained at 3 d after MCAO showed complete occlusion of the MCA; in addition, T2 hyperintensities were present unilaterally in the striatocapsular and cerebral cortex lesions. Partial occlusion of the proximal part of the MCA was identified in the 2 remaining dogs, with T2 hyperintensities present only in the striatocapsular lesions. The occluded sites were confirmed at necropsy. The results of this study demonstrate the potential of TOF-MRA to provide a detailed description of intracranial arteries and aid in the evaluation of flow impairment in a canine MCAO model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19295056/