Peer-reviewed veterinary case report
MRI features in a canine model of ischemic stroke: correlation between lesion volume and neurobehavioral status during the subacute stage.
- Journal:
- Comparative medicine
- Year:
- 2009
- Authors:
- Kang, Byeong-Teck et al.
- Affiliation:
- Department of Neurology · South Korea
- Species:
- dog
Plain-English summary
This study looked at how well magnetic resonance imaging (MRI) can help diagnose ischemic stroke, which is a type of stroke caused by a blockage of blood flow, in dogs. Researchers induced strokes in six healthy beagles and then used MRI to take pictures of their brains at different times after the stroke. They found that the size of the stroke-related brain damage was closely linked to how the dogs behaved and functioned. The results suggest that standard MRI techniques can be useful for diagnosing and understanding the effects of ischemic stroke in dogs during the early recovery phase.
Abstract
The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) and assess the correlation between the volume of the ischemic lesion and neurobehavioral status during the subacute stage of ischemic stroke. Ischemic stroke was induced in 6 healthy laboratory beagles through permanent occlusion of the middle cerebral artery (MCAO). T2-weighted and fluid-attenuated inversion recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), measurement of the apparent diffusion coefficient (ADC) ratio, and neurobehavioral evaluation were performed 3 times serially by using a 1.5-T MR system: before and 3 and 10 d after MCAO. Ischemic lesions demonstrated T2 hyperintensity, FLAIR hyperintensity, and DWI hyperintensity. The ADC ratio was decreased initially but then was increased at 10 d after MCAO. Ischemic lesion volumes on T2-weighted and FLAIR imaging were not significantly different from those on DWI. The lesion volume and neurobehavioral score showed strong correlation. Our results suggest that conventional MRI may be a reliable diagnostic tool during the subacute stage of canine ischemic stroke.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19887030/