Peer-reviewed veterinary case report
Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings.
- Journal:
- Journal of veterinary science
- Year:
- 2007
- Authors:
- Kang, Byeong-Teck et al.
- Affiliation:
- Department of Veterinary Internal Medicine · South Korea
- Species:
- dog
Plain-English summary
In this study, researchers looked at how ischemic stroke, which is a type of stroke caused by a blockage in blood flow to the brain, affects beagle dogs. They created this condition in four healthy beagles by blocking a specific artery in the brain. The dogs showed signs of brain problems, like being less responsive, turning their heads, circling, and having difficulty with balance and perception. Over four weeks, these symptoms improved on their own without any treatment. The study found specific changes in the brain's structure and function, indicating that this model can help us understand strokes in dogs similarly to how they occur in humans.
Abstract
The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17993751/