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Peer-reviewed veterinary case report

Granular Cell Tumor in the Brain of a Dog

Journal:
Brazilian Journal of Veterinary Pathology
Year:
2021
Authors:
Maglaty, Marisa & Woolard, Kevin D.
Species:
dog

Plain-English summary

A 10-year-old female spayed Golden Retriever/Poodle mix had a mass removed from her adrenal gland and was given a low dose of prednisone afterward. Eight days later, she started having clusters of seizures and was treated with levetiracetam, a medication for seizures. The next day, she was very tired and stumbling, and a neurological exam showed some coordination issues and delayed responses in her left limbs. Tests showed mostly normal results, but there was a slight increase in liver enzymes. An MRI scan revealed a mass in her brain that was causing serious problems, and because her condition was unlikely to improve, her owners chose to have her euthanized.

Abstract

10 year-old, female spayed, Golden Retriever/Poodle mix. This patient had a mass removed laparoscopically fromthe right adrenal gland (cortical adenoma) and was started on a low dose of prednisone post-operatively. Eight days postop,she began having cluster seizures and was started on levetiracetam therapy. The following day, the dog was moderatelyobtunded and stumbling. On neurological examination, mild generalized ataxia was noted along with decreased menace OS,and delayed proprioception in the left pelvic and left thoracic limbs. CBC and chemistry values were unremarkable except fora mild hepatic enzyme elevation. EEG showed seizure-like activity and abnormal brain waves resembling sleep state whileawake. MRI revealed an eccentric right-sided mass extending over the frontal and parietal lobes with subtentorial herniation.Due to poor prognosis, euthanasia was elected.

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Original publication: https://doi.org/10.24070/bjvp.1983-0246.v14i1p80-87