Peer-reviewed veterinary case report
Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2009
- Authors:
- Phillips, Brenda et al.
- Affiliation:
- Veterinary Specialty Hospital of San Diego · United States
- Species:
- dog
Plain-English summary
This study looked at how well dogs with appendicular osteosarcoma (a type of bone cancer) do after having their leg amputated and receiving a drug called carboplatin. The researchers reviewed records from 155 dogs treated at 14 different veterinary centers. They found that, on average, dogs lived about 307 days after treatment and had a disease-free period of about 256 days before the cancer returned. The results suggest that using carboplatin along with amputation can help improve survival compared to just amputation alone. Overall, the treatment worked well and is a good option for these dogs.
Abstract
Survival following amputation and administration of single-agent carboplatin for treatment of appendicular osteosarcoma (OSA) in dogs was retrospectively examined. Records of 155 dogs with appendicular OSA treated with amputation and single-agent carboplatin were included from 14 centers. Any carboplatin dosage, number of doses, and protocol schedule were eligible for inclusion. The median disease-free interval (DFI) was 256 days. The median overall survival time was 307 days. Similar prognostic survival factors were identified in this study as reported in prior studies of canine appendicular OSA. Median DFI and survival were comparable to those reported in the original Bergman et al publication. Carboplatin treatment improves the survival probability in dogs with appendicular OSA compared to amputation alone and remains an acceptable alternative to adjuvant treatment with cisplatin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19122062/