Peer-reviewed veterinary case report
Alternating carboplatin and doxorubicin as adjunctive chemotherapy to amputation or limb-sparing surgery in the treatment of appendicular osteosarcoma in dogs.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 2004
- Authors:
- Kent, Michael S et al.
- Affiliation:
- Department of Surgical and Radiological Sciences · United States
- Species:
- dog
Plain-English summary
In this study, 32 dogs with a type of bone cancer called appendicular osteosarcoma (which affects the limbs) underwent surgery, either amputation or a limb-sparing procedure, and then received additional chemotherapy. The chemotherapy involved alternating treatments with two drugs, carboplatin and doxorubicin, given every three weeks for a total of three cycles. The results showed that, on average, dogs lived about 320 days after treatment, with some living as long as 487 days. The side effects from the chemotherapy were minimal, and the researchers believe this treatment approach could be beneficial for dogs with this type of cancer.
Abstract
Thirty-two dogs with appendicular osteosarcoma treated by amputation or limb sparing had adjuvant chemotherapy of alternating doses of carboplatin (300 mg/m2 IV) and doxorubicin (30 mg/m2 IV) every 21 days for a total of 3 cycles. Efficacy, toxicity, and previously identified prognostic factors for osteosarcoma were evaluated. The median progression free survival was 227 days (range 180-274), and the median overall survival was 320 days (range 153-487). The 1-year survival rate was 48%, and the 2-year survival rate was 18%. Age, sex, surgical procedure, and alkaline phosphatase activity above the reference ranges were not prognostic for survival. There was minimal toxicity associated with the chemotherapy. This protocol could be useful for the adjuvant treatment of appendicular osteosarcoma of dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15320595/