Peer-reviewed veterinary case report
The chimpanzee model for hepatitis B virus infection.
- Journal:
- Cold Spring Harbor perspectives in medicine
- Year:
- 2015
- Authors:
- Wieland, Stefan F
- Affiliation:
- Department of Immunology and Microbial Science · United States
Abstract
Even before the discovery of hepatitis B virus (HBV), it was known that chimpanzees (Pan troglodytes) are susceptible to human hepatitis viruses. The chimpanzee is the only primate animal model for HBV infections. Much like HBV-infected human patients, chimpanzees can develop acute and chronic HBV infections and consequent hepatitis. Chimpanzees also develop a cellular immune response similar to that observed in humans. For these reasons, the chimpanzee has proven to be an invaluable model for investigations on HBV-driven disease pathogenesis and also the testing of novel antiviral therapies and prophylactic approaches.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26033082/