Peer-reviewed veterinary case report
Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.
- Journal:
- European journal of medicinal chemistry
- Year:
- 2004
- Authors:
- Kim, Bok Young et al.
- Affiliation:
- Chong Kun Dang Research Institute · South Korea
- Species:
- rodent
Abstract
A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKA(y) mice in vivo. On the basis of their biological activities, 5-(4-[2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy]benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15110969/