Peer-reviewed veterinary case report
Design, synthesis, and antihyperlipidemic evaluation of novel 2-[1-(substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2,3-d]pyrimidin-4(3H)-ones.
- Journal:
- Archiv der Pharmazie
- Year:
- 2013
- Authors:
- Arya, Nikhilesh et al.
- Affiliation:
- Department of Pharmaceutical Chemistry · India
- Species:
- rodent
Abstract
Novel thienopyrimidine derivatives of azetidinone possessing the combined features of the cholesterol absorption inhibitor drug ezetimibe and potential antihyperlipidemic 2-substitutedthienopyrimidin-4-ones were synthesized and characterized by spectroscopic data and elemental analysis. These compounds were evaluated for their lipid-lowering activity in Wistar albino rats. Some of them showed significant lipid-lowering effects comparable to those of the standard drug, gemfibrozil, at the same dose levels.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23881664/