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Peer-reviewed veterinary case report

Suspected systemic calcinosis and calciphylaxis in 5 horses.

Journal:
The Canadian veterinary journal = La revue veterinaire canadienne
Year:
2010
Authors:
Tan, Jean-Yin et al.
Affiliation:
Department of Veterinary Population Medicine · United States
Species:
horse

Plain-English summary

Five horses were brought in because they were showing signs of muscle problems and overall illness. Blood tests revealed high levels of fibrinogen (a protein that indicates inflammation), phosphorus, and a concerning combination of calcium and phosphorus in their bodies. After they passed away, the examination showed that they had systemic calcinosis, which means there was calcium buildup in various organs like the lungs, kidneys, muscles, and heart. This condition had not been reported in horses before. Unfortunately, the outcome was not positive, as all five horses did not survive.

Abstract

Five horses were presented with signs of myopathy along with systemic malaise, hyperfibrinogenemia, hyperphosphatemia, and an elevated calcium phosphorus product (Ca*P). Postmortem findings were consistent with systemic calcinosis, a syndrome of calcium deposition in the tissue of organs including lungs, kidneys, muscle, and heart that has not been previously described in horses.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/21119866/