Peer-reviewed veterinary case report
Paradoxic hypercalcemia and hypophosphatemia associated with chronic renal failure in horses.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1982
- Authors:
- Tennant, B et al.
- Species:
- horse
Plain-English summary
In a study involving six horses with chronic kidney failure, researchers found that these horses had high levels of calcium (hypercalcemia) and low levels of phosphorus (hypophosphatemia) in their blood. Five of the horses had kidney damage classified as chronic glomerulonephritis, while the sixth had chronic interstitial nephritis and pyelonephritis. The study ruled out other conditions that could cause high calcium levels, indicating that the kidney's role in managing calcium is different in horses with severe kidney problems. Overall, this suggests that the kidney issues in these horses are specifically linked to their chronic renal failure.
Abstract
Chronic renal failure associated with hypercalcemia and hypophosphatemia was diagnosed in 6 horses. The renal lesions in 5 of the horses were classified as chronic glomerulonephritis and in the sixth, as chronic interstitial nephritis/pyelonephritis. There was no evidence of primary hyperparathyroidism or pseudohyperparathyroidism, thus suggesting that hypercalcemia associated with advanced renal failure in horses is related to a unique role of the equine kidney in calcium homeostasis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/7068501/