Peer-reviewed veterinary case report
Successful management with CHOP for pulmonary lymphomatoid granulomatosis in a dog.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2011
- Authors:
- Hatoya, Singo et al.
- Affiliation:
- Department of Advanced Pathobiology · Japan
- Species:
- dog
Plain-English summary
A 3-year-old spayed female miniature dachshund was brought to the vet because she was vomiting and had stopped eating. X-rays and a CT scan showed unusual spots in her lungs. A biopsy confirmed she had pulmonary lymphomatoid granulomatosis, a type of lung disease involving abnormal immune cells. She was treated with a specific chemotherapy regimen called CHOP, and impressively, she lived for over 1,000 days after starting treatment. This case is notable as it is the first time this type of lung disease in dogs was successfully treated with CHOP chemotherapy.
Abstract
A 3-year-old, spayed female miniature dachshund was presented for vomiting and anorexia. Thoracic radiographs and CT scan revealed abnormal pulmonary opacities at bilateral caudal lobe. Cytological analysis of the pulmonary mass revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. An open lung biopsy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (LYG) was made. The dog was administered CHOP based therapy (modified UW-25), and it survived for 1,022 days after admission. Immunohistochemistry revealed pulmonary lesions consisted of many CD79a positive B cells aggregation and proliferation with prominent angiocentric pattern. This was the first case of canine pulmonary LYG managed by CHOP chemotherapy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21139353/