Peer-reviewed veterinary case report
CHOP chemotherapy for the treatment of canine multicentric T-cell lymphoma.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2011
- Authors:
- Rebhun, R B et al.
- Affiliation:
- Department of Surgical and Radiological Sciences · United States
- Species:
- dog
Plain-English summary
In this study, researchers looked at how effective CHOP chemotherapy, which includes medications like cyclophosphamide, doxorubicin, vincristine, and prednisone, is for treating dogs with multicentric T-cell lymphoma, a type of cancer. Out of 24 dogs treated, 23 showed a positive response and continued on the treatment for an average of about 146 days. The overall survival time for all the dogs was around 235 days, but those with low platelet counts at the start of treatment lived significantly longer, averaging 323 days compared to 212 days for others. Overall, the treatment was effective for most dogs in this study.
Abstract
Dogs with multicentric T-cell lymphoma are commonly treated with CHOP chemotherapy protocols that include cyclophosphamide, doxorubicin, vincristine and prednisone. The purpose of this study was to evaluate the use of CHOP chemotherapy for dogs with multicentric T-cell lymphoma. Identification of prognostic factors in this specific subset of dogs was of secondary interest. Twenty-three out of 24 dogs responded to CHOP chemotherapy and these dogs remained on the protocol for a median of 146 days. No variable was associated with progression free survival (PFS) including stage, substage, hypercalcemia or radiographic evidence of a cranial mediastinal mass. The median overall survival time (OST) for all dogs was 235 days. Dogs that were thrombocytopenic at presentation experienced a significantly longer OST (323 versus 212 days, P=0.01).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21303452/