Peer-reviewed veterinary case report
Retrospective analysis for treatment of naïve canine multicentric lymphoma with a 15-week, maintenance-free CHOP protocol.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2016
- Authors:
- Curran, K & Thamm, D H
- Affiliation:
- Colorado State University · United States
- Species:
- dog
Plain-English summary
In this study, researchers looked at a shorter treatment option for dogs with multicentric lymphoma, a type of cancer that affects multiple lymph nodes. They treated 134 dogs using a 15-week chemotherapy plan that combined four drugs: cyclophosphamide, doxorubicin, vincristine, and prednisone. An impressive 98% of the dogs responded to the treatment, with 104 of them showing no signs of cancer at all. On average, the dogs lived about 176 days without the cancer getting worse and around 311 days overall after starting treatment. This shorter, less intensive treatment plan seems to be a good alternative for pet owners who might find longer treatments challenging.
Abstract
Standard of care treatment of dogs with multicentric lymphoma includes combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP); however, owners may be hesitant to commit the resources necessary to complete a lengthy, multi-drug protocol. One hundred thirty-four client-owned dogs with multicentric lymphoma were treated with a 15-week CHOP chemotherapy protocol. The overall response rate was 98% with 104 dogs experiencing a complete response (CR). The median progression-free survival (PFS) time for all dogs was 176 days, and the median disease-specific overall survival time was 311 days. Prognostic factors identified on multivariate analysis as significant for PFS included substage, immunophenotype, hospitalization for adverse events, need for dose reduction, presence of neutrophilia at diagnosis, presence of anemia and experiencing a CR as best response to therapy. In conclusion, this protocol may be a viable alternative to CHOP protocols using a larger number of treatments.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26279153/