Peer-reviewed veterinary case report
Propofol modulates inner retina function in Beagles.
- Journal:
- Veterinary ophthalmology
- Year:
- 2007
- Authors:
- Kommonen, Bertel et al.
- Affiliation:
- Department of Clinical Veterinary Medicine
- Species:
- dog
Abstract
PURPOSE: To further understand a common veterinary anesthetic, propofol (2,6- di-isopropylphenol) and effects of infusion rates on the retinal neurons in Beagle dogs. METHODS: Standard full-field blue xenon-flash stimulation elicited responses of dark-adapted eyes, which were recorded from dogs before and after a propofol infusion rate increase. RESULTS: Electroretinogram b-waves increased significantly after the infusion rate increase and decreased with decline (P < 0.0001). Also, a weak significance (P = 0.041) for a-wave peak amplitude increase was found after infusion rate increase. The initial part (first 18 ms) of the leading edge of the a-wave remained unchanged. No significant differences in times to a- and b-wave peaks were found. CONCLUSION: Enhanced b-wave response and decline is due to sensitivity of postreceptoral cells, possibly interplexiform and amacrine cells, to propofol concentration.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17324161/