Peer-reviewed veterinary case report
Mouse models for immuno-oncology.
- Journal:
- Trends in cancer
- Year:
- 2023
- Authors:
- Bosenberg, Marcus et al.
- Affiliation:
- Department of Dermatology · United States
- Species:
- rodent
Abstract
Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms underlying treatment response as well as treatment limiting toxicity. Preclinical in vivo model systems and technologies are required to address these knowledge gaps and to surmount the challenges faced in the clinical application of immunotherapy. Mice are commonly used for basic and translational research to support development and testing of immune interventions, including for cancer. Here, we discuss the advantages and the limitations of current models as well as future developments.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37087398/