Peer-reviewed veterinary case report
Monoclonal proliferation of B-cells with two integration sites of bovine leukemia virus proviral DNA in cattle with enzootic bovine leukosis.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2024
- Authors:
- Maezawa, Masaki et al.
- Affiliation:
- Graduate School of Agricultural and Life Sciences · Japan
Abstract
The present study analyzed B-cell clonality and bovine leukemia virus (BLV) provirus integration sites in cattle with enzootic bovine leukosis (EBL) having BLV proviral copy numbers less or greater than the number of bovine nucleated cells. EBL cattle with BLV copy numbers less than the number of bovine nucleated cells showed monoclonal and biclonal proliferation of B-cells with one BLV provirus integration site. On the other hand, EBL cattle with BLV copy numbers greater than the number of bovine nucleated cells showed monoclonal proliferation of B-cells with two BLV provirus integration sites. These results suggest that superinfection of BLV can occur in EBL cattle.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38631888/