Peer-reviewed veterinary case report
Analysis of bovine leukemia virus integration sites in cattle under 3 years old with enzootic bovine leukosis.
- Journal:
- Archives of virology
- Year:
- 2020
- Authors:
- Maezawa, Masaki & Inokuma, Hisashi
- Affiliation:
- Department of Veterinary Medicine · Japan
Abstract
In the present study, we analyzed bovine leukemia virus (BLV) integration sites in under 3 years old with enzootic bovine leukosis (EBL) cattle and compared these to 30 cattle over 3 years old with EBL. BLV proviruses were integrated near CpG islands and into long interspersed nuclear elements more frequently in EBL cattle under 3 years old than in those over 3 years old. These results suggest that cattle under 3 years old with EBL have different BLV provirus integration sites from those of cattle over 3 years old with EBL, and the BLV provirus integration site may represent one factor contributing to early onset of EBL.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31624916/