Peer-reviewed veterinary case report
Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission.
- Journal:
- Journal of medical primatology
- Year:
- 2020
- Authors:
- Schmitt, Kimberly et al.
- Affiliation:
- Department of Microbiology · United States
- Species:
- rodent
Abstract
HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33460210/