Peer-reviewed veterinary case report
Metastatic esthesioneuroblastoma in a horse.
- Journal:
- Journal of comparative pathology
- Year:
- 2005
- Authors:
- Döpke, C et al.
- Affiliation:
- Institut fü · Germany
- Species:
- horse
Plain-English summary
A 17-year-old horse had a serious problem with its left eye, which bulged out over a period of a year and a half. After the horse passed away, a thorough examination revealed a tumor that had spread to several areas, including the left side of the skull and the eye itself. The tumor was made up of specific types of cells that showed certain characteristics under the microscope, leading to a diagnosis of metastatic esthesioneuroblastoma, which is a type of cancer that can spread from the nasal area. Unfortunately, the outcome was not favorable, as the horse did not survive.
Abstract
A 17-year-old horse developed severe proptosis of the left eye over a period of 1.5 years. At post-mortem examination a neoplasm was found involving the left ethmoid bone, left maxillary sinus, left orbit, left superior turbinate, and the left eye. Tumour cells were arranged in nests separated by a fine fibrovascular stroma. Immunohistochemically, the tumour cells were labelled by antibodies against neurofilament protein, synaptophysin, glial fibrillary acidic protein and S-100 protein antigen, but were negative for chromogranin A, cytokeratin and desmin. Electronmicroscopically, the cells showed neurosecretory granules with an electron-dense centre and a light halo, and microfilaments. On the basis of macroscopical, light microscopical and ultrastructural findings a diagnosis of a metastatic esthesioneuroblastoma was made.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15737348/