Peer-reviewed veterinary case report
Insulin-dependent diabetes mellitus associated with presumed autoimmune polyendocrine syndrome in a mare.
- Journal:
- The Canadian veterinary journal = La revue veterinaire canadienne
- Year:
- 2011
- Authors:
- Giri, Jill K et al.
- Affiliation:
- The Veterinary Medical Teaching Hospital · United States
- Species:
- horse
Plain-English summary
A 5-year-old Thoroughbred-cross mare was diagnosed with insulin-dependent diabetes mellitus, which means her body couldn't properly use insulin to control blood sugar levels. She received daily insulin injections for 18 months, which helped manage her blood sugar and improved her overall health. Unfortunately, she later showed signs of another serious condition called hypoadrenocorticism, which affects hormone production in the adrenal glands, and she ultimately passed away. A thorough examination after her death revealed that her pancreas, adrenal glands, and thyroid glands had been affected by an immune response, suggesting an autoimmune condition.
Abstract
A 5-year-old Thoroughbred-cross mare was diagnosed with insulin-dependent diabetes mellitus. Partial glycemic control and clinical improvement were achieved with daily insulin administration for 18 mo. The mare subsequently developed evidence of hypoadrenocorticism and died. Necropsy findings included lymphocytic infiltration of the pancreas, adrenal cortex, adrenal medulla, and thyroid glands, suggestive of an immune-mediated polyendocrinopathy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22043070/