Peer-reviewed veterinary case report
Diabetes mellitus associated with bilateral granulosa cell tumors in a mare.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1986
- Authors:
- McCoy, D J
- Species:
- horse
Plain-English summary
A 10-year-old American Saddle Horse mare had both of her ovaries larger than normal and had been struggling with infertility for the past three years. She was drinking and urinating a lot, had high levels of insulin and sugar in her blood, and didn't handle extra sugar well. Doctors found that she had tumors on both ovaries that were affecting her hormone levels and likely causing her diabetes. While the exact reason for the diabetes wasn't clear, it seemed to be linked to the tumors interfering with how her body processed sugar.
Abstract
Both ovaries in a 10-year-old American Saddle Horse mare were determined to be larger than normal. The mare had problems with infertility during the preceding 3 years. Clinical evaluation revealed that the mare was polyuric, polydypsic, hyperinsulinemic, and hyperglycemic, and had reduced tolerance to exogenous glucose. Bilateral granulosa cell tumors were identified on histologic examination of the ovaries. The precise mechanism for the secondary diabetes mellitus was not determined; however, the cause was suspected to be a result of the synthesis and release of a hormonal substance by the tumor that affected carbohydrate metabolism and resulted in decreased peripheral sensitivity to insulin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/3700232/