Peer-reviewed veterinary case report
Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis, and treatment selection.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2016
- Authors:
- Sledge, Dodd G et al.
- Affiliation:
- Michigan State University · United States
- Species:
- dog
Plain-English summary
Canine cutaneous mast cell tumors are skin tumors that can behave very differently in different dogs, making it challenging to decide on the best treatment. This study emphasizes the importance of using a careful, evidence-based method to create personalized treatment plans for dogs with these tumors. It discusses how to diagnose and predict outcomes based on various tests, including examining the tumor's characteristics and genetic factors. The authors suggest a combined approach that looks at both clinical signs and laboratory results to help veterinarians choose the right treatment. Overall, the findings aim to improve how these tumors are managed in dogs.
Abstract
In view of the varied biologic behavior and the costs of treatment for canine cutaneous mast cell tumors, development of appropriate treatment plans for individual affected dogs can be difficult, but decisions regarding treatment should be made using a systematic, evidence-based approach. This manuscript reviews the current state of diagnostics and prognostication of canine cutaneous mast cell tumors, and suggests a combined approach based on clinical and pathologic assessment for decision making regarding treatment choices. The current state of histologic grading, evaluation of proliferation indices, evaluation of mutations in the c-kit gene and KIT expression, evaluation of excision and clinical staging are examined. On the basis of the current understanding of prognostication and treatment response, algorithms for selection of local and systemic therapy are presented.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27372911/