Peer-reviewed veterinary case report
Bilaterally symmetric focal cortical dysplasia in a golden retriever dog.
- Journal:
- Journal of comparative pathology
- Year:
- 2014
- Authors:
- Casey, K M et al.
- Affiliation:
- Department of Pathology · United States
- Species:
- dog
Plain-English summary
A 10-year-old golden retriever was brought to the vet after having seizures for a day. An MRI of the dog's brain didn't show any problems, but sadly, the decision was made to euthanize the dog. A closer examination of the brain tissue revealed a condition called focal cortical dysplasia, which is a type of brain malformation that can lead to seizures. This specific case was unusual because this condition has not been reported in dogs before. Unfortunately, the treatment options were limited, and the outcome was not favorable.
Abstract
A 10-year-old golden retriever dog was referred with a 24-h history of generalized seizures. Magnetic resonance imaging of the brain found no abnormalities on 3 mm transverse sections and the dog was subsequently humanely destroyed. Microscopically there was bilaterally symmetrical focal disorganization of cortical grey matter within the tips of the right and left suprasylvian gyri of the temporal cortex. The focal abnormal cortical lamination was characterized by loss of pyramidal neurons with abnormal, irregular, angular, remaining neurons occasionally forming clusters, surrounded by fibrillary astrogliosis and microgliosis and vascular proliferation. These histological findings are consistent with focal cortical dysplasia, a cerebral cortical malformation that causes seizures in people, but not reported previously in the dog.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25246180/