Peer-reviewed veterinary case report
Bilateral hippocampal malformation and concurrent granulomatous meningoencephalitis in a dog with refractory epilepsy.
- Journal:
- Journal of comparative pathology
- Year:
- 2014
- Authors:
- Klang, A et al.
- Affiliation:
- Institute of Pathology and Forensic Veterinary Medicine
- Species:
- dog
Plain-English summary
A 5-year-old dog was taken to the vet because it had stopped eating and was very tired for three weeks, and then it experienced a serious seizure episode. Despite being treated with anti-seizure medications, the dog continued to have seizures and was sadly put to sleep ten weeks later. A closer look at the dog's brain showed that there were problems with a part of the brain called the dentate gyrus, which helps with memory, and there was also a severe inflammation affecting the brain and its coverings. This case is notable because it is the first time this specific brain malformation has been reported in a dog. Unfortunately, the treatment did not work, and the dog's condition did not improve.
Abstract
A 5-year-old dog was referred with a history of anorexia and apathy for 3 weeks and acute status epilepticus. Ten weeks later the animal was humanely destroyed due to refractory epilepsy despite anti-epileptic medical treatment. Microscopical examination of the brain revealed bilateral malformation of the dentate gyrus with abnormal gyration. Cornu ammonis segments comprised of sparse pyramidal cells accompanied by marked gliosis. Additionally, there was severe generalized disseminated granulomatous meningoencephalitis, mainly localized to the white matter of the cerebral hemispheres. This is the first description of bilateral hippocampal malformation in a dog.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24461687/