Peer-reviewed veterinary case report
Autoimmune polyendocrine syndrome with hypoadrenocorticism and diabetes mellitus in a dog: A rare case.
- Journal:
- Veterinary medicine and science
- Year:
- 2021
- Authors:
- Hwang, Seo-Young et al.
- Affiliation:
- Department of Veterinary Clinical Science · South Korea
- Species:
- dog
Plain-English summary
A 9-year-old spayed female miniature poodle was brought to the clinic because she had stopped eating, was very tired, and was vomiting. She had been diagnosed with insulin-dependent diabetes mellitus and tests showed low sodium and chloride levels, along with repeated low blood sugar episodes. The vet diagnosed her with hypoadrenocorticism (a condition where the adrenal glands don't produce enough hormones) after observing her symptoms and conducting specific hormone tests. After treatment with an injection and an increase in her oral medication, her overall health improved. This case is notable because it is the first reported instance of hypoadrenocorticism occurring alongside diabetes mellitus in a dog.
Abstract
BACKGROUND: Autoimmune polyendocrine syndrome, also called polyglandular autoimmune syndrome, is a rare immune-mediated disorder that involves various endocrine glands. PURPOSE: To report autoimmune polyendocrine syndrome in a dog. METHODS: A 9-year-old spayed female miniature poodle diagnosed with insulin-dependent diabetes mellitus emergently visited our clinic for anorexia, severe depression, and vomiting. Hyponatremia, hypochloridemia, and recurrent hypoglycaemia were found. Hypoadrenocorticism was diagnosed based on consistent clinical signs and repeated adrenocorticotropic hormone stimulation tests. RESULTS: After injecting deoxycorticosterone pivalate and increasing the oral prednisolone dose, the patient's systemic condition improved. CONCLUSIONS: To the best of our knowledge, this is the first case report of hypoadrenocorticism concurrent with diabetes mellitus in a dog. Furthermore, we would like to present the probability of an immune-mediated disorder with multiple organs involved, like type IV autoimmune polyendocrine syndrome in humans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34480407/