Peer-reviewed veterinary case report
A new reversible ischemic neurologic deficit model in dogs.
- Journal:
- Medical science monitor : international medical journal of experimental and clinical research
- Year:
- 2008
- Authors:
- Ogün, Cemile Oztin et al.
- Affiliation:
- Department of Anesthesiology and Intensive Care
- Species:
- dog
Plain-English summary
In this study, researchers created a model in dogs to better understand how to treat certain brain conditions caused by reduced blood flow. They performed surgery on five mixed-breed dogs, blocking a major artery in the brain and then monitored them using advanced imaging techniques. After the surgery, all the dogs experienced weakness on one side of their bodies, but this improved and returned to normal within a week to ten days. The imaging showed initial brain damage that became less severe over time. The findings suggest that this model can be useful for studying brain conditions that can improve with treatment.
Abstract
BACKGROUND: The aim of this study was to produce an internal carotid artery (ICA) occlusion model in dogs that can be used for studying the effects of surgical revascularization procedures. MATERIAL/METHODS: After left frontoparietal craniectomy, the ICA and arterial circle of the brain were coagulated and transected, letting the middle cerebral artery be perfused by the contralateral ICA by way of the rostral cerebral artery in five mongrel dogs. Magnetic resonance imaging (MRI) and brain single-photon emission computed tomography (SPECT) were performed during the first 24 to 48 hours and 7 to 10 days after the operation. Paired t and Wilcoxon matched pair tests were used for statistics (p<0.05). RESULTS: All the dogs had postoperative hemiparesis that returned to normal after 7 to 10 days. Early MRI showed cerebral ischemia in the left parietal cortical area extending to the subcortical white matter, sparing the basal ganglion and the internal capsule. Early brain SPECT demonstrated hypoperfusion corresponding to the same area. This area became significantly restricted to a small cortical area in late MRI and SPECT images (p<0.05). CONCLUSIONS: It is concluded that, as symptoms resolved spontaneously, this model can be used as a "reversible ischemic neurological deficit" model for diagnostic imaging and pharmacological studies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18830186/