Peer-reviewed veterinary case report
Utility of serum cystatin C as a clinical measure of renal function in dogs.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2008
- Authors:
- Wehner, Astrid et al.
- Affiliation:
- Department of Small Animal Internal Medicine · Germany
- Species:
- dog
Abstract
A human kit for cystatin C determination was evaluated for use with canine sera. A reference range was also established. The association between cystatin C and glomerular filtration rate (GFR) was evaluated in 60 dogs with various diseases, by using exogenous creatinine plasma clearance (ECPC) as a measure of GFR. The correlation between cystatin C and ECPC (correlation coefficient [r] = -0.630; P<0.001) was stronger than the correlation between serum creatinine and ECPC (r = -0.572; P<0.001). Nonrenal diseases (e.g., neoplasia, infection) did not influence serum cystatin C concentration. Test sensitivity was significantly better (P<0.001) for cystatin C (76%) than for creatinine (65%). Specificities for the two tests were 87% and 91%, respectively.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18451071/