Peer-reviewed veterinary case report
Use of immunohistochemical marker calretinin in the diagnosis of a diffuse malignant metastatic mesothelioma in an equine.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2004
- Authors:
- Stoica, G et al.
- Affiliation:
- Department of Veterinary Pathobiology · United States
- Species:
- horse
Plain-English summary
This report discusses a rare case of a type of cancer called diffuse malignant metastatic mesothelioma in a 6-year-old gray Arabian mare. The mare showed signs of illness, including fluid buildup in her abdomen and chest, and roughening of the lining in her chest cavity. During the examination after her passing, doctors found a lot of fluid in her body and noticed that her organs had thickened surfaces with raised bumps and bleeding. The cancer was found to have spread from its original site, likely in the heart area, to other parts of her body. This case is significant because it is the first time a specific marker called calretinin was used to help diagnose this type of cancer in a horse.
Abstract
Mesotheliomas are rarely reported in animal species. In this report, the occurrence of a diffuse, metastatic mesothelioma in a 6-year-old gray Arabian mare is described. The mare was presented on clinical examination with ascites, bilateral pleural effusion, and pleural roughening. Necropsy revealed abundant fluid in the abdominal and thoracic cavities. The surface of all organs was thick and fibrosed with multiple raised nodules and hemorrhages. Histology was characteristic of a generalized, biphasic mesothelioma with vascular and lymph nodes metastases. It is believed that the primary tumor developed in the pericardium and spread through lymphatics. In this report, calretinin was used as an immunohistochemical marker in the diagnosis of mesothelioma in an equine species for the first time.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15152842/