Up-expression of GAD65 in the amygdala of the rat model of chronic immobilization stress with elevated blood glucose.

Abstract

It is considered that hypothalamus is important in the regulation of the blood glucose, but how chronic stress leads to hyperglycemia is not known. In this experiment, we used chronic immobilization stress rat as a model, and observed that only rats with increased expression of GAD65 in the amygdala had an elevated level of blood glucose. Considering there are fiber tracks between the amygdala and hypothalamus, some of which are GABAergic, this result may indicate that the change of GAD65 expression in the amygdala may be related to changes in blood glucose levels. Therefore, the amygdala may be involved in the hyperglycemic response to stress.