Peer-reviewed veterinary case report
Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.
- Journal:
- Hypertension in pregnancy
- Year:
- 2020
- Authors:
- Cunningham, Mark W et al.
- Affiliation:
- Department of Pharmacology & Toxicology · United States
- Species:
- rodent
Abstract
UNLABELLED: The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS).  Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats. METHODS: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19. RESULTS: MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN. CONCLUSION: TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32646252/