Peer-reviewed veterinary case report
Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2009
- Authors:
- Ho, Koc-Kan et al.
- Affiliation:
- Ligand Pharmaceuticals · United States
- Species:
- rodent
Abstract
The profile of a series of triazine and pyrimidine based ROCK inhibitors is described. An initial binding mode was established based on a homology model and the proposed interactions are consistent with the observed SAR. Compounds from the series are potent in a cell migration assay and possess a favorable kinase selectivity. In vivo activity was demonstrated for compound 1A in a spontaneous hypertensive rat model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19800787/