Peer-reviewed veterinary case report
Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury.
- Journal:
- Metallomics : integrated biometal science
- Year:
- 2018
- Authors:
- Portbury, Stuart D et al.
- Affiliation:
- The Florey Institute of Neuroscience and Mental Health · Australia
- Species:
- rodent
Abstract
Zinc (Zn) deficiency is a clinical consequence of brain injury that can result in neuropathological outcomes that are exacerbated with age. Here, we present laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging data showing modulation of brain Zn levels by the disaccharide trehalose in aged mice following a controlled cortical impact model of traumatic brain injury. In this proof-of-concept study, trehalose induced an increase in brain zinc levels, providing important preliminary data for larger studies using this simple carbohydrate as a modulator of this essential micronutrient in traumatic brain injury. Our results may have further implications for the treatment of a variety of neurodegenerative diseases and other disorders of the nervous system.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29872801/