Peer-reviewed veterinary case report
Treatment Options for Melanoma of Gray Horses.
- Journal:
- The Veterinary clinics of North America. Equine practice
- Year:
- 2019
- Authors:
- MacKay, Robert J
- Affiliation:
- Department of Large Animal Clinical Sciences · United States
- Species:
- horse
Abstract
All gray horses inherited a single gene mutation, STX17, that unbalances melanocyte behavior to cause graying and propensities to develop vitiligo and melanoma. The coat color genes ASIPand MC1Radd risk such that relative likelihood of melanoma based on pregraying coat color is black > bay > chestnut. Melanomas begin at about 4 years. Locoregional control of melanoma masses depends on surgical removal and/or intralesional chemotherapy (possibly with adjunctive hyperthermia or electroporation). Systemic treatment is not evidence based but immunomodulators (cimetidine, levamisole) and vaccines can be tried.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31279435/