Peer-reviewed veterinary case report
Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Zheng, Tong et al.
- Affiliation:
- McKnight Brain Institute · United States
- Species:
- rodent
Abstract
Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16919606/