Peer-reviewed veterinary case report
Tractable Cre-lox system for stochastic alteration of genes in mice.
- Journal:
- Nature methods
- Year:
- 2008
- Authors:
- Miller, Ashleigh J et al.
- Affiliation:
- Oregon Health & Science University · United States
- Species:
- rodent
Abstract
We developed a cell division-activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status and occurs in individual cells surrounded by normal tissue, mimicking spontaneous cancer-causing mutations. This system should be particularly useful for delineating pathways of neoplasia, and determining the developmental and aging consequences of specific gene alterations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18264106/