Peer-reviewed veterinary case report
Three equine cases of mixed hepatoblastoma with teratoid features.
- Journal:
- Veterinary pathology
- Year:
- 2007
- Authors:
- Loynachan, A T et al.
- Affiliation:
- University of Kentucky · United States
- Species:
- horse
Plain-English summary
Three Thoroughbred horses at the University of Kentucky were diagnosed with a rare liver tumor called mixed hepatoblastoma, which has some unusual characteristics. In the first case, a fetus had a distinct mass in the liver. The second case involved a newborn horse with a liver mass that had spread to the skin, brain, and other areas. The third case was a liver mass found during an examination after a newborn horse had died. All three cases showed similar patterns of abnormal cells and other tissue changes.
Abstract
Hepatoblastoma was diagnosed in 3 Thoroughbreds at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997. Case #1 involved a fetus with a well-demarcated, multilobulated, solitary mass that extended from the left liver lobe. Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone. Case #3 was a solitary hepatic mass incidentally discovered in a neonate at necropsy. Microscopically, the masses were similarly composed of sheets and cords of fetal and embryonal epithelial cells that frequently formed sinusoid-like structures. Intermixed with the neoplastic epithelial cells were variable amounts of hemorrhage, necrosis, osteoid, and bone. Immunohistochemically, the epithelial cells stained variably positive for alpha- fetoprotein, frequently positive for vimentin, and occasionally positive for cytokeratin. All 3 cases were diagnosed as mixed hepatoblastoma with teratoid features.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17317799/