Peer-reviewed veterinary case report
The use of trilostane for the treatment of alopecia X in Alaskan malamutes.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2005
- Authors:
- Leone, F et al.
- Affiliation:
- Clinica Veterinaria Adriatica · Italy
- Species:
- dog
Abstract
Three Alaskan malamutes with hair loss and slightly elevated blood concentrations of 17-hydroxyprogesterone after stimulation with adrenocorticotropic hormone (ACTH) were treated with trilostane. Trilostane, an inhibitor of 3 beta-hydroxysteroid dehydrogenase, was given twice daily at a dose of 3.0 to 3.6 mg/kg per day orally for 4 to 6 months. Routine ACTH stimulation tests were performed over 8 months to evaluate the degree of adrenal function suppression. Treatment with trilostane led to complete hair regrowth in all three dogs within 6 months. No adverse effects associated with trilostane were recognized.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16141187/