Peer-reviewed veterinary case report
The Use of Murine Infection Models to Investigate the Protective Role of TNF in Central Nervous System Tuberculosis.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2021
- Authors:
- Hsu, Nai-Jen & Jacobs, Muazzam
- Affiliation:
- Department of Pathology and Institute of Infectious Disease and Molecular Medicine
- Species:
- rodent
Abstract
Tuberculosis of the central nervous system (CNS-TB) is the most severe form of extra-pulmonary tuberculosis that is often associated with high mortality. Secretion of tumor necrosis factor (TNF) has important protective and immune modulatory functions for immune responses during CNS-TB. Therefore, by combining the approaches of aerosol and intracerebral infection in mice, this chapter describes the methods to investigate the contribution of TNF in protective immunity against CNS-TB infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33185878/