Peer-reviewed veterinary case report
The Use of Galleria mellonella (Wax Moth) as an Infection Model for Group A Streptococcus.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2020
- Authors:
- Tsai, Catherine Jia-Yun et al.
- Affiliation:
- Department of Molecular Medicine and Pathology
Abstract
Recently, the use of Galleria mellonella larvae as a nonmammalian model to simulate bacterial infectious diseases has shown to be a rapid, simple, and cost-effective alternative. The insect's innate immune response is remarkably similar to that of the vertebrates, and consists of both the cellular and the humoral immune response. Here, we provide a protocol for using G. mellonella larvae to study virulence of GAS, including the use of a health score system for quantitative analysis and the methods for assessing post-infection bacterial burden in vivo.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32430829/