Peer-reviewed veterinary case report
The Study of Efficiency of the Approach to Prevent the Adhesions in the Abdominal Cavity of Rats.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2021
- Authors:
- Karpov, M A et al.
- Affiliation:
- Research Institute of Experimental and Clinical Medicine
- Species:
- rodent
Abstract
Adhesions in rat abdominal cavity were studied after laparotomy and subsequent single intraperitoneal injection of 2 ml of 5% aqueous solution of oxidized dextran (OD) with a molecular weight of 40 kDa (oxidation degree 10%). On days 7 and 21 after laparotomy, the number of adhesions in OD-treated rats was lower by 7.5 and 4 times than in animals not receiving OD. The number of neutrophils in adhesions on day 21 was manyfold lower in OD-treated rats. In 7 and 21 days after laparotomy, the number of fibroblasts in the adhesions of rats receiving and not receiving OD was similar, but 2-fold higher than in the peritoneum of non-operated rats. The content of collagen in adhesions on day 21 after laparotomy in OD-treated rats was 10-fold lower than in animals no receiving OD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34542744/