The roles of differentstrains in alleviating DSS-induced ulcerative colitis and related functional genes.

Abstract

is a common intestinal bacterium closely associated with host colitis. However, relevant studies have been focused on the genus level, which could not identify the majorspecies associated with intestinal disease. Thus, we have evaluated thespecies structure in healthy people and mouse intestinal tracts and explored the change in majorspecies during colitis development. The results demonstrated thatwith a high abundance in the intestinal tract of healthy people and mice may be a core species that contributes to colitis remission. The results of animal experiments reported thatFNMHLBE1K1 (1K1) could alleviate the severity of colitis and enhance the expression of the tight junction protein occludin by regulating gut microbiota. Notably, the protective roles of 1K1 may be attributed to some specific genes. This study revealed thatis a key microbe influencing the occurrence and development of colitis and it provides a scientific basis for screening the next generation of probiotics.