Peer-reviewed veterinary case report
The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.
- Journal:
- Microbes and infection
- Year:
- 2020
- Authors:
- Keck, Jonathon et al.
- Affiliation:
- University of Texas at San Antonio · United States
- Species:
- rodent
Abstract
Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32084556/