Peer-reviewed veterinary case report
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.
- Journal:
- Nature neuroscience
- Year:
- 2008
- Authors:
- Lutter, Michael et al.
- Affiliation:
- Department of Psychiatry · United States
- Species:
- rodent
Abstract
We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18552842/