The morphology and pathogenesis of lesions in mice brain cortex under influenza virus A (H3N1 1/62) infection.

Abstract

The aim of study was to reveal pathologic changes of brain cortex nervous elements in influenza A virus infection in experiment and to clarify neural disturbances by analyzing their ultrastructural findings in mice under experimental influenza virus infection in first 16 days of experiences. Ultrastructural and histological appearance also volume fraction of neurons from parieto-temporal cortex in 6-week-old mice were carried out after 24, 48-72 hours and 5-16 days of intranasal inoculation of influenza virus A (H3N1 1/62) Hong Kong. Nerve cells in layer V of the cerebral cortex of mice respond to infection with influenza virus by complex changes: acute swelling, chromatolysis, vacuolization, shrinkage and neuronophagia. Quantitative changes in the "acute" phase of infection up to 72 hours to testify of cortex cytoarchitectonic in the form of lower differentiation and higher monotony size of neurons with their polarization from very small cells to large, hypertrophied, which is unusual for the "intact" model of brain.