The Interplay Between Thyroid Disorders and Diabetes and Their Impact on Cardiovascular Outcomes: A Systematic Review.

Abstract

Diabetes mellitus and thyroid diseases are closely related, as both conditions share pathophysiological pathways and risk factors that increase cardiovascular risk. The purpose of this research is to thoroughly examine the literature about the connection between thyroid conditions and diabetes mellitus and determine how these conditions affect cardiovascular outcomes. PubMed, Google Scholar, Science Direct, and BioMed Central (BMC) databases were analysed using keywords "thyroid dysfunction", "hypothyroidism", "hyperthyroidism", "diabetes", "diabetes mellitus", "cardiovascular illness", and "cardiovascular outcomes". A comprehensive search of databases yielded studies published between 2011 and 2024, focusing on human subjects and the interplay between thyroid function and diabetes. The articles selected are screened for selection. A total of 4205 papers were selected after screening. After duplicate removal, 1185 articles were selected and underwent review, and 12 articles were chosen for quality appraisal using the Newcastle-Ottawa Scale for cross-sectional studies. Eight articles qualified the criteria for selection and quality appraisal. There is a bidirectional relationship between thyroid dysfunction and diabetes, underscoring the need for comprehensive management to mitigate cardiovascular risk found in this review. Regular thyroid screening, monitoring of cardiovascular risk factors, and timely intervention are crucial. Future research should prioritise longitudinal studies, standardised protocols, and molecular insights to inform evidence-based practice and optimise patient outcomes.