The Influence of Bariatric Surgery on Serum Level of Nesfatin-1: A Systematic Review and Meta-Analysis.

Abstract

<h4>Background</h4>Obesity is an escalating worldwide health issue, and bariatric surgery has demonstrated efficacy as a strategy for substantial weight reduction and metabolic improvement. Nesfatin-1, an anorexigenic peptide, is associated with appetite control and energy balance; nevertheless, its response following bariatric surgery is variable. This meta-analysis assesses the effects of bariatric surgery on BMI and nesfatin-1 concentrations in individuals with obesity.<h4>Methods</h4>A comprehensive literature search was performed in PubMed, Scopus, Embase, and Web of Science, according to PRISMA criteria. Included were studies examining pre- and post-surgical alterations in BMI and nesfatin-1 levels. A random-effects meta-analysis was conducted to evaluate aggregated effect sizes, heterogeneity, and possible publication bias.<h4>Results</h4>Seven trials with a total of 237 patients were examined. Bariatric surgery resulted in a substantial decrease in BMI (-10.23, 95% CI: -13.00 to -7.46; <i>p</i> < 0.001), exhibiting moderate-to-high heterogeneity (<i>I</i>² = 84.16%). Nesfatin-1 levels demonstrated a non-significant increase following surgery (10.22, 95% CI: -3.42 to 23.86; <i>p</i> = 0.14) and considerable heterogeneity (I² = 99.98%). The funnel plot indicated little publication bias, however the Galbraith plot identified probable outlier research that contributed to variability.<h4>Conclusion</h4>Bariatric surgery markedly decreases BMI, underscoring its importance in obesity management. The impact on nesfatin-1 levels remains ambiguous due to significant variability and variances specific to each studies. Additional study employing standardized procedures and extended follow-up durations is necessary to clarify the function of nesfatin-1 in post-surgical metabolic control.