Peer-reviewed veterinary case report
The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection.
- Journal:
- Journal of virology
- Year:
- 2013
- Authors:
- Shin, Eui-Cheol et al.
- Affiliation:
- National Institute of Diabetes and Digestive and Kidney Diseases · United States
Abstract
T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23388706/