Peer-reviewed veterinary case report
The epileptic thalamocortical network is a macroscopic self-sustained oscillator: evidence from frequency-locking experiments in rat brains.
- Journal:
- Scientific reports
- Year:
- 2015
- Authors:
- Velazquez, J L Perez et al.
- Affiliation:
- Hospital for Sick Children · Canada
- Species:
- rodent
Abstract
The rhythmic activity observed in nervous systems, in particular in epilepsies and Parkinson's disease, has often been hypothesized to originate from a macroscopic self-sustained neural oscillator. However, this assumption has not been tested experimentally. Here we support this viewpoint with in vivo experiments in a rodent model of absence seizures, by demonstrating frequency locking to external periodic stimuli and finding the characteristic Arnold tongue. This result has important consequences for developing methods for the control of brain activity, such as seizure cancellation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25672543/