The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit

Abstract

The aim of this study was to investigate and evaluate the effects of colloidal silver and hypochlorous acid solutions on wound healing. To evaluate the wound healing activity of colloidal silver solution and hypochlorous acid solutions, an in vivo excisional wound model was applied in New Zealand rabbits (n = 21). The rabbits were randomly divided into 3 groups with seven individuals in each group. Group 1 was used as a negative control and no treatment was applied. Groups 2 and 3 were treated with crystalline (hypochlorous acid) and colloidal silver, respectively. The treatments were applied topically (in the form of spray) to the wound area of each rabbit daily. Wound diameters were measured on days 4, 8 and 12 using calipers and histopathological examinations were performed on days 4, 8 and 12 of the treatment. In terms of wound closure, both hypochlorous acid and colloidal silver solutions showed comparable wound healing activity with the control group. In conclusion, hypochlorous acid and colloidal silver have a positive effect on dermal wound healing in rabbits.